The youth of South Hillsborough County attended Wimauma School, grades 1 through 12, located in Wimauma, Florida, through the 1956-57 school year.

East Bay High School was chartered in the fall of 1957. The original location served grades 7 through 12 and is the current Eisenhower Middle School.

In 1972, the current East Bay High School building was contructed and housed grades 10 through 12. In 1974, the ninth graders were transferred from the middle school, and our grade structure of 9 through 12 is still intact today.